Abstract
Chitosan (CS) is known for excellent biodegradability and low immunogenicity. However, its low water solubility has hampered CS biomedical application. In this study, we aimed to modify CS with polyethylene glycol (PEG) to improve water solubility and explored the possibility to use as a drug delivery vehicle. Degree of substitution of PEG on CS was varied, ranged from 16% to 78%. After dispersing in water, CS-PEG750 and CS-PEG5000 could spontaneously form small nanoaggreagtes (NGs) at low concentration, with critical aggregation concentration ranged from 32 μg/mL to 112 μg/mL. Upon encapsulation of curcumin, all NGs were slightly bigger in size. CS-PEG750 (1:40) NGs showed the highest entrapment efficiency at 59%, while CS-PEG5000 (1:40) and (1:60) NGs exhibited 36.9% and 36.5% entrapment efficiency, respectively. With few steps of modification, this modified CS copolymers reveal improved water solubility and decent entrapment efficiency. Thus this copolymer is a potential contender as a drug delivery vehicle.
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