Abstract
Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best known representative drug from the compound class of arylcyclohexylamines. On an account of pharmacological activities it belongs to the family of drugs known as a dissociative anesthetics. In recent years, great attention has been paid to the investigation of the substances that have been abused, including PCP. PCP is the synthetic drug with stimulant and hallucinogens effects (street name ?angel dust?) and it's situated on the Schedule Substances List, in Serbia and worldwide. In the beginning, PCP has been sold in pharmacies as local anesthetic, but very quickly it was pulled from sale because of the unwanted effects on consumer?s health causing psychoactive addiction. Taking into the account that today a great attention has been given to the substances that are subject of abuse, in this paper, biological and pharmacological effect of PCP and it's derivative is described. It is shown that PCP is antagonist of N-methyl-D-aspartate (NMDA) and that it causes antiglutamateric hallucinations. Unlike BTCP which agonist is NMDA receptor and is obtained by modifying the structure of PCP. This paper presents a PCP metabolism and provides an overview of the methods for their identification and quantification in the biological samples. Immunological tests of PCP in the biological samples can provide a quick but wrong result because of the possible interference with the other substances of abuse as opposed to instrumental methods. Based on the presented method and the results it was concluded that the method of choice for the examinations of biological samples for the presence of PCP is gas chromatography in combination with mass spectroscopy.
Highlights
Fenciklidin (PCP) ili 1-fenil-cikloheksilpiperidin spada u klasu arilcikloheksilaminskih derivata i po svojoj farmakološkoj aktivnosti pripada familiji disocijativnih anestetika
Pokazano je da je PCP antagonist N-metil-D-aspartat (NMDA) receptora, koji blokira aktivnost NMDA receptora te dovodi do antiglutamatergičnih halucinacija
Na osnovu rezultata koja su dobijena kvalitativnim i kvantitativnim ispitivanjem PCP u biološkim uzorcima može se zaključiti da su hromatografske i spektrografske metoda najosetljivije za razdvajanje i detekciju PCP
Summary
Fenciklidin (PCP) ili 1-fenil-cikloheksilpiperidin spada u klasu arilcikloheksilaminskih derivata i po svojoj farmakološkoj aktivnosti pripada familiji disocijativnih anestetika. PCP je sintetička droga sa stimulativnim i halucinogenim dejstvom, koja se prvobitno pojavila u apotekama kao lokalni anestetik, ali je vrlo brzo povučena iz prodaje zbog neželjenih efekata po zdravlje njenih konzumenata i postala je predmet zloupotrebe. U radu je prikazan metabolizam PCP kao i pregled metoda za njegovo dokazivanje i kvantifikaciju u biološkim uzorcima jer se nalazi na tzv. Fenciklidin (PCP) jeste psihotropna supstanca pod međunarodnom kontrolom (United Nations Convention on Psychotropic Substances 1971), a u Srbiji u skladu sa Zakonom o proizvodnji i prometu opojnih droga i psihotropnih supstanci nalazi se na tzv. Godine započela proizvodnju PCP hidrohlorida pod komercijalnim imenom „Sernil“, ali je nakon dve godine proizvod povučen iz prodaje zbog svojih neželjenih efekata [4]. Godine pojavljuje pod novim nazivom „Sernilan“ kao veterinarski anestetik, ali je takođe ponovo povučen iz prodaje. PCP ima preko 30 derivata koji po svojim farmakološkim dejstvima spadaju u disocijativne anestetike koje dovode do većih ili manjih halucinogenih i stimulativnih efekata u odnosu na PCP
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
