Synthesis and characterization of PEG coated hollow Fe3O4 magnetic nanoparticles as a drug carrier

Abstract

As a drug carrier, the properties of magnetic nanoparticles for drug loading are significant. In this letter, three different shapes of magnetic nanoparticles for drug carrier systems were compared. We synthesized Fe3O4 magnetic nanospheres, nanorings and nanotubes, and plyethylene glycol was used as a surface modifier for drug loading. The structure characterization of three different shapes of Fe3O4 nanoparticles was elucidated by electron microscopy, and the composition was analyzed by Fourier transform infrared. The drug loading status and drug release of the three types of nanoparticles with different shapes were tested by Ultraviolet Spectrophometometer. The results show that the hollow Fe3O4 magnetic nanorings and nanotubes have better drug loading capacity and are more suitable for drug carriers, compared with nanospheres.