Abstract

Abstract Rutin is one of the biologically active functional components present in a wide range of pharmacological applications. Herein, we reported the preparation of selective electrochemical sensor based on poly(3,4-ethylene-dioxythiophene) (PEDOT)-mesoporous carbon (MC) for rutin determination. The composite material was synthesized by in-situ polymerization and characterized using different analytical techniques such as FT-IR and SEM to evaluate the composition and the morphology. Cyclic voltammetry was performed for the electrochemical characterization of different modified electrodes and the parameters influencing the sensitivity of PEDOT-MC/AgNPs toward rutin such as accumulation time and pH were optimized. Under optimal conditions, the modified electrode provides a wide linear range and low limit of detection using differential pulse voltammetry (DPV). The GCE/PEDOT-MC/AgNPs electrochemical sensor shows high sensitivity, long duration stability, and good reproducibility and the PEDOT-MC/AgNPs have been successfully used for the detection of rutin in real samples.

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