Abstract
Two novel oxidovanadium(IV) complexes with a new bidentate (O- and N-) imine-based ligand 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol (HL) were synthesized under in situ experimental condition where VOSO4 acts as a kinetic template in the ratio 2 : 1 (L : M) and mixed ligand complex using 1,10-phenanthroline (phen) in 1 : 1 : 1 (L : M : phen) ratio. The synthesized compounds were structurally characterized by microanalysis, magnetic susceptibility, FTIR, electronic spectra, TG/DTA, ESR, and molar conductance studies. Based on the spectral studies, the complexes have the general composition [VO(L)2] (C1) and [VO(L)phen] (C2) in a square pyramid geometrical fashion. The synthesized compounds were primarily screened for their in vitro growth inhibiting activity against different strains of bacteria, namely, E. coli, B. subtilis, S. aureus, and P. aeruginosa by the disc diffusion method. Also, the antifungal activity was determined against C. albicans and A. niger by the Bateman poisoned technique. The in vitro antioxidant activity of all the compounds was determined by DPPH free radical-scavenging assay. Intercalative mode of DNA-binding properties of the oxidovanadium(IV) complexes with calf-thymus DNA (CT-DNA) was investigated using UV, fluorescence spectra, and viscosity measurements.
Highlights
Vanadium compounds, especially the coordination chemistry of oxidovanadium(IV), have aroused significant interest for several main reasons in recent years especially in the designing of long-acting drugs in metabolism
Research interest in oxidovanadium chemistry derives from its utility in several biological and industrial processes like antimicrobial, spermicidal, antioxidant, antitumor, DNA binding [1], and recently as insulin mimetic [2]. e vital role of vanadium in different chemical and biological systems has motivated the development of vanadium chemistry. e coordination chemistry of nitrogen and oxygen donor ligand is an active area of research
Transition metal complexes of vanadium with imine bases have been amongst the most widely studied of coordination compounds in the past few years since they are found to be important as analytical and antimicrobial agents. e complexes formed by 3d metals with ligand using both oxygen and nitrogen have been paid close attention in this area
Summary
Especially the coordination chemistry of oxidovanadium(IV), have aroused significant interest for several main reasons in recent years especially in the designing of long-acting drugs in metabolism. Transition metal complexes of vanadium with imine bases have been amongst the most widely studied of coordination compounds in the past few years since they are found to be important as analytical and antimicrobial agents. E transition metal complexes of 1,10-phenanthroline have been widely employed in DNA studies due to their utility in biomedicinal chemistry and in the design of stereospeci c DNA-binding drugs [9]. In this perspective, it is essential to know the antioxidant and DNA binding properties of bioactive compounds for their use in the pharmaceutical and therapeutic eld. E current study is structured to provide a synthesis and characterization of a new imine-based ligand (HL) and its oxidovanadium(IV) complexes. e new compounds have been subjected to characterize by di erent analytical techniques and exploit some biological applications of oxidovanadium complexes
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