Synthesis and Characterization of Novel Hydrazone Based Anti-mutagenic and Antioxidative Agents

Emrah Giziroglu,Cengiz Sarikurkcu,Nurdan Sarac

doi:10.7324/japs.2015.510.s9

Abstract

Synthesis and trypanocidal activity of salicylhydrazones and p-tosylhydrazones of S-(+)-carvone and arylketones on African trypanosomiasisBienvenu GLINMA, Fernand A. GBAGUIDI, Urbain C. KASSEHIN, Salomé D.S. KPOVIESSI, Alban HOUNGBEME, Horrhus D. HOUNGUE, Georges C. ACCROMBESSI and Jacques H. POUPAERT

Highlights

There are several biologically active organic compounds present significant application in the bioorganic chemistry
Over the years, too many compounds including hydrazone-barbiturates and hydrazone-oximes moiety have been synthesized, there are very few examples mentioned about antioxidant activity, tyrosinase inhibition activity and mutagenic or antimutagenic potential (Giziroglu et al, 2013; Khan et al, 2011; Zaragoza-Dörwald, F. 2012)
When we look at the reducing power assay, we used two different test system namely cupric ion reducing (CUPRAC) and ferric reducing antioxidant power (FRAP)

Summary

Introduction

There are several biologically active organic compounds present significant application in the bioorganic chemistry. Besides on behalf of their biological importance, hydrazone derivatives containing barbiturate or oxime moiety possess diverse pharmacological activities. These types compounds were named by hydrazone-barbiturates and hydrazone-oximes which are typically act as tridentate, bidentate or monodentate compounds reacting through the oxygen or imine nitrogens depending on the reaction conditions (Neumann et al, 2014; Giziroglu et al, 2013; Gup et al, 2006). Antioxidant and antimutagenic effects of Survey of literature revealed that there are several reports on antimicrobial, antitubercular, anticonvulsant, antitumor and anti-inflammatory activities concerning the structures of such molecules with hydrazone, barbiturate and oxime groups Due to the limited information, we selected antioxidant, antimutagenic and tyrosinase inhibitory properties of new hydrozane derivatives as biological activity parameters

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Conclusion