Abstract
Some new tetrazole derivatives were prepared by the reaction between the prepared azomethine compounds I6-I10 with sodium azide in anhydrous tetrahydrofuran (THF) with a few drops of distilled water and under reflux conditions. Azomethine compounds were prepared by thermal condensation reactions of aromatic aldehydes with primary aromatic amines. The prepared compounds (tetrazole derivatives) were screened for their antibacterial activity (by disc diffusion method). Compound I6 is the most active derivative that has recorded a significantly (p<0.01) stronger influence to inhibit the growth of Candida zeylanoides with an average zone of inhibition of 26.0 mm. Derivatives I7 and I9 showed the lowest zone of inhibition of 8.0 mm against Candida zeylanoides. This study may be helpful in designing more potential anticandidal agents for therapeutic use in the future.
Highlights
Azomethine compounds discovered by Hugo Schiff in 1864, can be prepared by different methods, one of the more important being the condensation reaction between primary amine with aldehyde.[1]
An example of one of tetrazole derivatives is the product from the reaction between azomethine compound
The best yield achieved for the prepared azomethine compounds was for compounds I3 82% and I4 84%, while the lowest yield was for compound I1 78% and the best yield of the prepared tetrazole derivatives was for I10 92%, while the lowest yield was for I6 76%
Summary
Azomethine compounds discovered by Hugo Schiff in 1864, can be prepared by different methods, one of the more important being the condensation reaction between primary amine with aldehyde.[1]. Tetrazole derivatives are heterocyclic compounds containing four nitrogen atoms and one carbon atom within one ring.[8] Tetrazoles as a group of heterocyclic compounds appear in IR spectra as broad signals; having peculiar biological activities.[9,10] Tetrazole derivatives have a special structure and can display anti-bacterial properties, such as antiviral and anti-allergic.[11,12,13] There are several methods to prepare tetrazole derivatives, and each method depends on the constituents of the reaction.[14] Recently, there were many various types of compounds (including such containing a metal centre coordinated with suitable ligands) tested against Candida albicans, with a varying degree of success.[15,16,17] An example of one of tetrazole derivatives is the product from the reaction between azomethine compound The products were identified by their melting points, FT-IR and 1H NMR spectra
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