Abstract
The present study involves the synthesis of substituted novel ethyl 2-oxo-2H-selenopyrano[2,3-b]quinoline-3-carboxylates (4a-f) by the reaction of 3-formyl-2-selenoquinolines (3a-f) with diethyl malanoate in the presence of piperidine. 3-Formyl-2-selenoquinolines (3a-f) were prepared by the action of NaHSe on substituted 2-chloroquinoline-3-carbaldehydes (2a-f). A series of 2-chloroquinoline-3-carbaldehydes (2a-f) were synthesized from substituted acetanilides (1a-f) using available protocol method. The structures of all the newly synthesized compounds were characterized by their elemental analysis, IR, 1H NMR, 13C-NMR and mass spectral data. All the newly synthesized compounds (4a-f) were evaluated for antimicrobial activities. Among the compounds tested, 4d and 4e were highly active against S. aureus and M. roseus.
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