Synthesis and Characterization of Novel Diclofenac (DCF) Derivatives

Abstract

AbstractOver the years, scientific community has shown immense interest in the synthesis of novel, bioactive molecules with few adverse effects. Instead of painstaking multistep synthesis with hazardous synthetic reagents, also for clinical studies, it is better to enhance the activity and tuning by structural modification of the commercial drugs based on their structural and biological properties. It is demonstrated that diclofenac (DCF) be an effective analgesic and anti‐pyretic in the treatment of cancer‐related pain, but it has limitations and adverse effects as gastrointestinal irritation, small intestine damage, nausea, platelet dysfunction, and vertigo. Wherefore the main objective of the current research is to investigate new, novel, green methods of preparation of DCF derivatives, and structural characterization with the help of FT‐IR, UV‐Visible spectroscopy, MS spectrometry techniques.