Abstract
In this study, chalcones were synthesis by condensing 2-acetylpyridine with aromatic aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. After that, new heterocyclic derivatives such as Oxazine, Thiazine and Pyrazol were synthesis by reaction between chalcones with urea, thiourea and hydrazine hydrate respectively scheme 1. All these compounds wrer characterization by FTIR, 1H-NMR spectroscopy and elemental analysis.
Highlights
Chalcones either natural or synthetic and their heterocyclics are known to exhibit various biological activities 1
Thiazine is fairly basic diuretics supplement it reduces water and increase vascularity, so it use as anabolic agent in medicine 18
After completion of the reaction (Scheme 1), the reaction mixture was poured into crushed ice and the precipitate have been obtained and recrystallized from ethanol . 2- General procedure for the Preparation of thiazine/oxazine derivatives [A1-A3, B1-B3] A mixture of Chalcone [1-3]
Summary
Chalcones either natural or synthetic and their heterocyclics are known to exhibit various biological activities 1. 1- General procedure for the preparation of chalcones (1-3) After completion of the reaction (Scheme 1), the reaction mixture was poured into crushed ice and the precipitate have been obtained and recrystallized from ethanol . 2- General procedure for the Preparation of thiazine/oxazine derivatives [A1-A3 , B1-B3] A mixture of Chalcone [1-3]
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