Synthesis and characterization of new heterocyclic compounds containing imidazolodine, triazolidine-3-thion, oxazepine derivatives and studding the biological activity

Abstract

This research included preparing the Schiff base (A) from condensation the Benzophenone with 2,4- dinitrophenyl hyrazine, via refluxed reaction or microwave method and comparing by them, the prepared of Imidazolidine derivatives (A1-A3) by reacting (A) with the amino acids Tyrosine, Alanine and Valine respectively, then react (A) with KSCN to form Triazolidine-3-thion (A4), then react (A) with the Anhydride of Succinic Anhydride and Maleic Anhydride to Prepare the sevenths rings of Oxazepane (A5) and Oxazepene (A6), respectively. The reaction was followed by (TLC) technique, iodine was used as a moderator, and the melting degrees were measured after purification of the prepared derivatives. The infrared (FT-IR) spectra were recorded using a Shimadzu FTIR-Prestige Fourier transform infrared Spectrophotometer (4000-400) Cm−1, used KBr disk University of Kufa / College of Pharmacy. The spectra of Proton NMR (1 H NMR) were recorded using (1H-NMR- Bruker-UItra Shield-300MHz Switzerland, with DMSO-d6) Shahid Baheshti university, (Tehran).