Abstract
The new diisocyanide ligand L possessing a polyether backbone was synthesized and its complexing ability towards metal such as 99mTc, Cu and Re was evaluated. Using the γ-emitting 99mTc isotope (at the non-carrier added level), L led to the formation of a cationic species whose biodistribution in Swiss mice revealed a moderate but lasting heart uptake. No redox properties of the ligand were observed by complexation since reaction with a Cu II salt led to the formation of a Cu II complex, characterized by EPR, IR and elemental analysis. Rhenium complexation gave two new chelates [Re IIICl 3PPh 3L] and [Re I 3]BPh 4, identified by IR NMR, elemental analysis and conductimetric studies. The usefulness of rhenium chemistry to approach 99mTc properties is discussed.
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