Synthesis and characterization of new compounds of amic acids derived from cephalosporins, the study of some physical applications and evaluation of their biological activity

Abstract

In this research, amino acids were prepared from the reaction of cephalosporins with anhydrous acids, and the accuracy of the prepared compositions was confirmed by measuring their physical properties, including melting point, molecular weight and colour, as well as through spectroscopic measurements, including Uv, FTIR, 1H-NMR, 13C-NMR, mass spectrometry, (S.E.M.), (C.H.N.). A study of electrical conductivity and a survey of the biological activity of some prepared compounds and on four types of pathogenic bacteria, two of which are Gram-positive, and two are Gram-negative. They are each of (Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumonia, and Pseudomonas putida). The use of Acker-Hinton's type of culture medium (Molar Hunting Agar) and aqueous solutions of the two compounds [DM7] were also prepared. [DM3] and in concentrations (0.01,0.001,0. 0001,0.00001) mg/ml and by using a solvent dimethyl sulfoxide (DMSO), a sensitivity test was conducted for the bacteria isolates that were used in the study by diffusion method, and using the antibiotics Cefixime, Ceftriaxone, Ampicillin as a control sample.