Abstract

Synthesis and Characterization of Nanoporous Hydroxyapatite with High Hemocompatibility

Highlights

  • Hydroxyapatite is a useful biomaterial with a composition similar to that of the human bone and has an excellent biocompatibility, bioactivity as well as non-immunogenicity [1]

  • This study reveals the effectiveness of the hydrothermal technique for producing nanoporous hydroxyapatite targeted for adsorption based biomedical applications

  • It is necessary to conduct hemocompatibility study especially hemolysis test on the nanoporous hydroxyapatite to ensure the safety of patients.In this study, nanoporous hydroxyapatite was synthesized based on a surfactant-templating system using decyltrimethylammonium bromide (C10TAB)

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Summary

Introduction

Hydroxyapatite is a useful biomaterial with a composition similar to that of the human bone and has an excellent biocompatibility, bioactivity as well as non-immunogenicity [1]. Commercial hydroxyapatite exhibits very low porosity and it cannot be used effectively for adsorption based biomedical applications, especially drug delivery, protein and nucleic acid fractionation [2]. Hydroxyapatite with high porosity is a valuable biomaterial for adsorption-based biomedical applications as it promotes better adsorption capacity and kinetics. Calcination is a heat treatment process used to prepare hydroxyapatite with high purity and uniform particle size, it is commonly applied in hydroxyapatite synthesis process.Hemocompatibility is a vital study to be performed prior to the utilization of hydroxyapatite in blood related biomedical applications. It is necessary to conduct hemocompatibility study especially hemolysis test on the nanoporous hydroxyapatite to ensure the safety of patients.In this study, nanoporous hydroxyapatite was synthesized based on a surfactant-templating system using decyltrimethylammonium bromide (C10TAB). The effect of calcination on the physicochemical properties and hemocompatibility of the synthesized hydroxyapatite is studied

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