Abstract
In this paper a convenient method for the preparation of N-fluoroalkylsulfonamides will be discussed. Methods have been developed for the introduction of fluoro-groups into the N-alkyl-sulfonamides by reaction with fluorogenat inorganic oxidizers [F 2/Ar (1–3%), XeF 2]. Under the action of XeF 2 or F 2, N-alkyl-sulfonamides undergo fluorination to form N-fluoroalkylsulfonamides in yields of more than 70%: ▪ R′ = R″ = Ph R″ = CH 3, nCH 3C 6H 4 R‴ = H, Na, K The compounds were identified by IR, NMR-F, and PMR spectroscopy methods and by chemical analysis.
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