Synthesis and Characterization of Magnetic Drug Carriers Modified with Tb3+ Ions.

Dorota Nieciecka,Dariusz Cichy,Paulina Końska,Michał Żuk,Paweł Krysiński,Aleksandra Rękorajska

doi:10.3390/nano12050795

Abstract

The study aimed to synthesize and characterize the magnetic drug carrier modified with terbium (III) ions. The addition of terbium extends the possibilities of their applications for targeted anticancer radiotherapy as well as for imaging techniques using radioisotopes emitting β+, β−, α, and γ radiation. The synthesis of iron oxide nanoparticles stabilized with citrates using the co-precipitation method (IONP @ CA) was carried out during the experimental work. The obtained nanoparticles were used to synthesize a conjugate containing terbium ions and guanosine-5′-monophosphate as an analog of drugs from the thiopurine group. Conjugates and their components were characterized using Transmission Electron Microscopy, infrared spectroscopy, X-ray microanalysis, spectrofluorimetry, and thermogravimetric analysis. The hybrid was also investigated with Langmuir layers to check the interaction with analogs of biological membranes.

Highlights

A lot of scientific attention is nowadays paid to magnetic nanoparticles (MNP) [1,2]. many materials can form magnetic nanoparticles—pure metals, metal alloys, or metal oxides—iron oxides seem to play the most significant role
We present an advanced magnetic conjugate composed of Iron oxide nanoparticles (IONPs) covered with a layer of citric acid (CA) with guanosine-50 -monophosphate (GMP) and Tb3+
The formation and physicochemical characterization of the conjugates was performed at each step of their synthesis

Summary

Introduction

A lot of scientific attention is nowadays paid to magnetic nanoparticles (MNP) [1,2]. Many materials can form magnetic nanoparticles—pure metals, metal alloys, or metal oxides—iron oxides seem to play the most significant role. Iron oxide nanoparticles (IONPs) are built of magnetite (Fe3 O4 ) or maghemite (Fe2 O3 ), or—more often—of nonstoichiometric iron oxides [3]. For years, they were believed to be biocompatible and low toxic [4], it turned out that toxicity needs further studies and depends on the way of administration and on coating, dosage, and hydrodynamic diameter [5,6]. IONPs can be used simultaneously in therapies and diagnostics of different types of cancers [9], making them suitable for theranostics [10]

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