Abstract
The present study seeks to synthesize, characterize, and sustain the release of properties of Ketotifen Fumarate Intercalated Zn–Al Layered Double Hydroxides (Zn-Al-KF-LDHs) by the chemical co-precipitation method. A variety of techniques were used to analyze the synthesized products, including Elemental Analysis, X-ray diffraction (XRD), Scanning electron microscope (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), and Thermogravimetry Differential Thermal Analysis (TG-DTA). The XRD patterns successfully highlighted the remarkable crystallinity of the typical hydrotalcite-like materials, Zn-Al-KF-LDHs. While the FT-IR analysis indicates the chemical functional groups and interlayer anions of Zn-Al-KF-LDHs, the elemental analysis determines the content of Zn, Al, S, C, H, and N. The TG-DTA results show that Zn-Al-KF-LDHs possess improved thermal stability. These findings provide an empirical understanding of the supramolecular structure of Zn-Al-KF-LDHs, enabling its comprehensive structural analysis. Additionally, the sustained-release properties of simulated gastric juice and intestinal juice, which followed the theoretical models of Higuchi and Riger-Peppas, indicated that the layered double hydroxides have potential applications as sustained-release carriers for ketotifen fumarate.
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