Abstract
Cyclodextrins (CD) are macrocyclic biopolymers with potential applications in the delivery of small and macro-molecular therapeutic agents. Despite the potent host-guest inclusion property, their inherent lack of cellular binding ability has limited applications in drug delivery. Herein, we functionalized b-cyclodextrin (b-CD) with diminazene aceturate(DIMA), which are bioactive molecules, widely distributed some cells, and responsible for antiprotozoal activity. The inclusion complex of DIMA with b-CD was confirmed with textural, thermogravimetric, calorimetric, spectroscopic, and microscopic techniques. Thus, the proposed inclusion complex b-CD-DIMA system could be used as a site-specific drug delivery carrier.
Highlights
Cyclodextrins (CD) are macrocyclic biopolymers with potential applications in the delivery of small and macro-molecular therapeutic agents
The isotherm of adsorption / desorption and the poresize distribution curves for diminazene aceturate/ βcyclodextrinis complex is shown in figure 1
The stability of the inclusion complex was determined both in the presence of inert as in the presence of air
Summary
Cyclodextrins (CD) are macrocyclic biopolymers with potential applications in the delivery of small and macro-molecular therapeutic agents. In another paper [20], increasing the solubility of nifedipine in water by beta-cyclodextrin complexing and the influence of the preparation method on dissolution were studied. The object of this study was to investigate the molecular structure of the diminazene aceturate/CD complex by BET analysis, thermogravimetric analysis, DSC, FTIR and TEM methods, and find some new corelation between the structure and characteristics. Complex preparation and characterization The diminazene aceturate/β-cyclodextrin (DIMA/β-CD)
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