Synthesis and Characterization of Hydroxypropyl Sesbania Galactamannan Seed Gum for Pharmaceutical Application

Abstract

The core focus of current research is chemical polysaccharide modification in pharmaceutical applications. The gum is made from the endosperm of Sesbania grandiflora Plant seeds that belongs to family Leguminosae. Both water-soluble and waterinsoluble gum were present in the Sesbania seed powder; the water-soluble gum was removed during purification, yielding a 30% purification yield. In order to increase the applications of partially hydroxypropyl Sesbania gum, the modifications indicated here entail adding hydroxypropyl groups to the molecule under a variety of different conditions. Among the factors that were looked at were the etherifying agent concentration, alkaline volume, and preparation medium parameters, including the reaction time and temperature. The degree of substitution (DS) was raised, which boosted the unaltered gum’s solubility, stability, and viscosity. Increases in an etherifying agent and alkali concentration, volume, reaction duration, and temperature increase DS from 0.4 to 0.7. The finished product was characterized using IR spectroscopy, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, rheologic property, solubility, swelling index, and gel fraction analysis of batch F1 as an improved batch. The alternate method for developing drug-loaded nanoparticles for controlled release dosages form by suing hydroxypropyl Sesbania gum.