Abstract
Hesperetin derivatives were synthesized through the esterification of acid chlorides with hesperetin under ambient reaction conditions with good yields. The product was confirmed using different spectral techniques. It was treated on zebrafish embryos to study the lethality, phenotypic deformities, and toxicity level of the compound. In that assessment, embryos showed lethality towards 3e at the minimal concentration. It assesses slow heartbeat since the compound loaded, the curvature on the back, upcurved fish, Cardiac chamber bulging, and poor survival rate in 72 h. 3a shows less toxicity more than other compounds. It shows only pericardial edema at higher concentration and 3c induced pericardial edema and upcurved tail at a medium range of the concentration. But both compounds were shown a good survival ratio at the minimal concentration.
Highlights
Hesperetin is a flavanone class of flavonoids
Most of the antibiotics and compounds were screened in zebrafish embryos assessment [15, 16, 17]. zebrafish is a sensitive model organism with a strong history of use in the evaluation of developmental neurotoxicity and ecotoxicology
We focused on the synthesis of Hesperetin derivatives, and these were evaluated for the lethality and toxicity level in zebrafish (Danio rerio) embryo model and further evaluation for potential drug compound
Summary
Hesperetin is a flavanone class of flavonoids. It's abundant in oranges and grapefruits, tomatoes, and cherries [1]. The multiple OH groups which confer greater antioxidant potency than are possessed by other flavanones [8, 9] It passes through the blood-brain barrier into the brain and exerts neuroprotective effects [10, 11]. In basic chemically synthesized compounds different from normal compounds These properties are restricted toxicity and the binding site upon the dosage level of the compounds. Developing derivatives of hesperetin molecule can help in identifying potential alternate compounds as an efficient anti-inflammatory, antioxidant, anti-carcinogenic, and neuroprotective effects. We focused on the synthesis of Hesperetin derivatives, and these were evaluated for the lethality and toxicity level in zebrafish (Danio rerio) embryo model and further evaluation for potential drug compound
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