Abstract
The role of low-density lipoprotein cholesterol (LDL-C) as a major risk factor for coronary heart disease (CHD) is well established [1-5]. Hemoperfusion treatment for familial hyperlipidemia (FH) and serious cardiovascular diseases is currently employed when the reduction of low-density lipoprotein (LDL) in patient’s plasma concentration appears impossible to be achieved by diet or drugs administration [6.7]. Since late 1970s, many scientists have been engaged in developing different kinds of adsorbents which included non-specific, selective adsorbents and immunoadsorbents [8]. Up to date, Polyacrylate coated polyacrylamide (DALI) extracorporeal LDL apheresis [9.10], and heparin-induced extracorporeal LDL apheresis Precipitation [11] had been developed. Most of the LDL adsorbents were used in plasma for the removal of LDL-C and a primarycell/plasma separation by a centrifuge or a membrane separator was required [12]. So far no corresponding observation was reported for the heparin immobilized PAN-based resin. In this paper, the resin was synthesized and the properties or factors affecting its adsorption were investigated.
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