Abstract
Novel glucose-grafted biodegradable amphiphilic glycopolymers P(AGE-glucose)- b-PLA were synthesized through a facile and efficient way. First, the block copolymer intermediates PAGE- b-PLA bearing double bonds in the side chains were synthesized by ring-opening polymerization of LA using PAGE as macroinitiator and Sn(Oct) 2 as catalyst; Then, 2-mercaptoethyl-β-glucoside (MEGlu) was conjugated to the side chains of PAGE- b-PLA via free-radical coupling reaction to give the glycopolymer P(AGE-glucose)- b-PLA. The micellization behavior of the glycopolymers P(AGE-glucose)- b-PLA in aqueous media was investigated by fluorescence (FL), 1H nuclear magnetic resonance spectroscopy ( 1H NMR), dynamic light scattering (DLS), and transmission electron microscope (TEM). The results showed that these glycopolymers P(AGE-glucose)- b-PLA formed spherical micelles with diameters about 200 nm.
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