Abstract
Cuprous halide mediated decomposition of (diethoxyphosphinyl)difluoromethylzinc bromide, (EtO) 2P(O)CF 2ZnBr, forms the title bisphosphonates in 50% isolated yield. The 19F and 31P NMR spectra of these isomeric bisphosphonates exhibit non-first order AA‘'XX’' patterns. Computer simulation permitted the determination of the J P-F, J F-F, and J P-P coupling constants for these compounds. Silylation and hydrolysis of the bisphosphonate mixture gave the silylated bisphosphonates and bisphosphonic acids respectively, as expected. Metathesis of the zinc reagent also yielded phenyl (diethoxyphosphinyl)difluoromethyl- mercury, (EtO) 2P(O)CF 2HgPh, in good yield. However, attempts to generate fluoro(diethoxyphosphinyl)carbene from this mercurial were unsuccessful.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
