Abstract
Morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe3O4 magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release behavior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted morin drug delivery.
Highlights
With dramatic progress in biomaterials and biomedical applications, huge amount of new and more promising drugs are discovered and designed
APTES is absorbed on the magnetite nanoparticles surfaces by Fe-O-Si bands, the coating of APTES is established by the presence of stretching vibration of CH2 bonds on aminopropyl group appeared at 2922 and 2850 cm−1 which confirmed the binding of APTES molecules at the surface of magnetite (APTES-magnetic nanoparticles (MNPs)) [19], and the bands around 1089 and 1193 cm−1 corresponded to the presence of SiO-H and Si-O-Si groups in Figure 2(b). [17]
The Transmission Electron Microscope (TEM) analysis revealed that the average particle size increased to 26.7 nm after APTES coating
Summary
With dramatic progress in biomaterials and biomedical applications, huge amount of new and more promising drugs are discovered and designed. Fe3O4 core serves as a carrier for magnetic targeting, while silica coating such as 3-aminopropyltriethoxysilane (APTES) on the Fe3O4 NPs offers sites for further modifications [10]. This APTES can bind to MNPs by adsorption or covalent bonding (MNPsAPTES), and through the active amino group in its structure it is able to combine with anti-cancer drug morin (MR). Fe3O4 magnetic nanoparticles were fabricated by co-precipitation method and coated with APTES. This MNPs-APTES were used as drug carriers. MR drug is loaded onto it and its loading and in vitro drug release profile was studied
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