Abstract
Synthesis and characterization of dimeric steroids based on 5-oxo-4,5-seco-yne units linked by a diyne spacer
Highlights
M. et al Steroids are a family of lipophilic compounds that are widespread in nature
The interesting chemical, biological and physical properties of the rising number of steroid dimers isolated from living organisms or obtained by synthesis[3,4,5,6,7] has prompted intensive activity in this developing field
In a previous publication we described the synthesis of dimeric terephthalates derived from epimeric 4,5-seco-cholest-3-yn-5-ols that display novel supramolecular networks in the solid state in which the facial hydrophobicity of the steroidal skeletons plays an important role.[8]
Summary
Steroids are a family of lipophilic compounds that are widespread in nature. Their intrinsic biological activity has kept this kind of compound in the focus of attention for more than a century. The subfamily of steroid dimers added its first members when a few compounds were isolated from nature[1] or occurred as by-products of various reactions.[2] The interesting chemical, biological and physical properties of the rising number of steroid dimers isolated from living organisms or obtained by synthesis[3,4,5,6,7] has prompted intensive activity in this developing field
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