Abstract
Stable hyaluronic acid nanogels were obtained following the water-in-oil microemulsion method by covalent crosslinking with three biocompatible crosslinking agents: Divinyl sulfone, 1,4-butanediol diglycidyl ether (BDDE), and poly(ethylene glycol) bis(amine). All nanoparticles showed a pH-sensitive swelling behavior, according to the pKa value of hyaluronic acid, as a consequence of the ionization of the carboxylic moieties, as it was corroborated by zeta potential measurements. QELS studies were carried out to study the influence of the chemical structure of the crosslinking agents on the particle size of the obtained nanogels. In addition, the effect of the molecular weight of the biopolymer and the degree of crosslinking on the nanogels dimensions was also evaluated for BDDE crosslinked nanoparticles, which showed the highest pH-responsive response.
Highlights
The majority of drugs display very poor aqueous solubility, resulting in poor bioavailability and pharmacokinetics in vivo [1,2,3]
This paper describes the synthesis and characterization of hyaluronic acid (HA) nanogels prepared by crosslinking reactions in the reverse microemulsion medium with different crosslinking agents: Divinyl sulfone (DVS), 1,4-butanediol diglycidyl ether (BDDE), and poly(ethylene glycol) bis(amine) (PEGBNH2 )
This study provides helpful conclusions about the control of the particle size and the swelling behaviour of HA nanogels to be used as promising biomaterials for future drug delivery applications
Summary
The majority of drugs display very poor aqueous solubility, resulting in poor bioavailability and pharmacokinetics in vivo [1,2,3]. For this reason, the load of water-insoluble compounds in delivery carriers is always an important issue. Nanogels are three-dimensional hydrogel nanoparticles based on crosslinked hydrophilic polymeric networks that have become very promising materials for drug delivery due to their relatively high encapsulation capacity These swellable polymer networks have a high capacity to hold water (i.e. body fluids), making them generally biocompatible, and do not dissolve into the aqueous medium. They are capable of holding molecular therapeutics and Polymers 2019, 11, 742; doi:10.3390/polym11040742 www.mdpi.com/journal/polymers
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