Synthesis and Characterization of Core-Shell Mesoporous Iron oxide Magnetic Nanoparticles using Modified Co-Precipitation Method

Abstract

In recent era, development of nanotechnology is an art of delivery of drug by improving its compatibility, effectiveness and efficacy. Among all nanoparticles, magnetic nanoparticles play a predominant role to shows their targeted drug delivery using a magnetic field, also helps to diagnose the diseases like cancer. The present study included preparation of four different mesoporous nanoparticles using the Pluronic block copolymer P123 as a surfactant template, then insert iron oxides using co-precipitation method. The resulted formed mesoporous magnetic nanoparticles are examined for structural characters by using FTIR, XRD, HRSEM and Elemental Mapping techniques. The results of X-ray diffraction (XRD) showed that the formed composites conserved ordered mesoporous structure after the formation of iron oxide nanoparticles in the pores. FTIR results indicated that the surface contains silanol group and Fe–O on the surface of the materials at 1060 cm-1 and 1020 cm-1 peaks respectively. Scanning electron microscopy (SEM) results showed that all mesoporous magnetic nanoparticles within the range of size from 50 to 100nm also possessed a regular spherical shape. These particles possessed high surface area, high pore volume and showed magnetic response sufficient for drug targeting in the presence of an external magnetic field. Elemental mapping data indicated about the percentage of all elements present in the mesoporous materials. We concluded that all four types of magnetic nanoparticles are structurally arranged in their structure with sufficient percentage of elements on their particle surface along with good size range. Further loading of drug into all types of magnetic nanoparticles decides the loading efficiency, stability and drug release nature.