Synthesis and characterization of copper (I) particles as contrast agents in magnetic resonance imaging

Abstract

Recent studies have focused on the link between metals and neurodegenerative diseases like multiple sclerosis (MS), particularly emphasizing the role of copper (Cu). Essential for vital functions, Cu imbalances can contribute to MS-related neurodegeneration and cerebral lesions. Interestingly, Cu accumulation could be a potential biomarker in magnetic resonance image (MRI) for MS. This study aimed to obtain copper(I) oxide nanoparticles (Cu2O-NPs) and evaluate their effectiveness in MRI as contrast agents or MS biomarkers. These nanoparticles were synthesized using the sol-gel method and analyzed via X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). MRI images were obtained introducing Cu2O-NPs into a cranial phantom at various concentrations and inversion times. Results showed that changes in MRI signal and longitudinal relaxation rate (T1) are associated with nanoparticle concentration, highlighting the potential of Cu2O-NPs in MRI applications for MS.