Synthesis and characterization of copolymers of β-cyclodextrin derivatives

Abstract

Cyclodextrins (CDs) are cyclic oligosaccharides made up of d-glucose units connected by 1,4-glucosidic linkages. β-CD is a cyclical starch derivative containing seven glucopyranose units. β-CD derivatives have characteristic property of larger surface area, robust mechanical strength, high surface to volume ratio, electrical and optical properties for analyte determination, good dispersion, easy removal of the template, surface modification, functionalization and handling capacity. In this work, an attempt is made to prepare succinyl-β-CD-acrylamide (S-β-CD-AA) copolymer and β-CD-malic anhydride (β-CD-MAH) copolymer. For the synthesis of S-β-CD-AA, S-β-CD derivative is prepared and further, acrylamide (AA) along with cross-linker undergoes free radical copolymerization for the formation of gel like product. The degree of succinylation (DS) of β-CD derivative is estimated. S-β-CD-AA copolymer showed potential swelling, and deswelling characteristic. Another copolymer is prepared from β-CD malic anhydride derivative. Further, the derivative is treated with cellulose and ethylene diamine tetra acetate (EDTA) to form β-CD-MAH copolymer. The two derivatives are characterized by several techniques. Thermal stability of these copolymers is estimated with the help of thermogravimetric analysis. The basic characterization of the presence of functional groups is done using UV–visible spectroscopy, and infrared spectroscopy. The elemental analysis helped to estimate C, H, N, S in the synthesized compounds. The surface morphology characterization is done with the help of scanning electron microscopy. X-ray diffraction analysis helped in determination of crystal structure of β-CD-MAH. β-CD derivatives prepared may be potential candidate to prepare inclusion complex, in drug delivery, drug loading and several similar applications.