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Abstract
Use nanohydroxyapatite into the polymeric matrix as bioactive material for bone tissue engineering has enormous therapeutic potential because beneficial properties biocompatibility, biodegradability, and consider a major inorganic constituent of the bone matrix. The blended films of Chitosan and Polyvinyl alcohol with Genipin as cross-link agent were studied with and without addition Nanohydroxyapatite. Samples were prepared by solvent casting. The resulting films blended composite were characterized by Fourier transfer infrared (FTIR) spectroscopy, degradation behavior, swelling degree and tensile strength. Degree of swelling, and weight loss of the films blended composite was decreased with an increase of genipin and nanohydroxyapatie concentrations while tensile strength was increased with an increase of genipin and nanohydroxyapaite concentrations. The results showed that the chitosan composite could be used as effective biomaterials for bone regeneration engineering with different degradation rates.
Highlights
Biodegradable polymers have been used as biomaterials for tissue engineering, wound healing, and drug delivery systems
Chitosan powder (CS): polyvinyl alcohol (PVA) blended showed another peek at 1743cm1 indicates the occurrence interaction bet Figure 1, C, and Figure 2 peaks locate in 1251cm-1, 1406 cm-1, 1630 cm-1 linked to C-O, CH3, C=C bonds, respectively [16]
The tensile strength of CS: PVA films blended with different concentrations of genipn and nanohydroxyapatite was determined; the results appeared that the tensile strength of the films blended increased with increased genipin concentrations and nanohydroxyapatie percentage
Summary
Biodegradable polymers have been used as biomaterials for tissue engineering, wound healing, and drug delivery systems. Genipin used as cross-linking agent for chitosan, collagen and proteins to improve various properties [5]. Chitosan blended with different biodegradable materials such as polyvinyl alcohol (PVA) that almost used in applications for tissue engineering to improve mechanical properties and cell attachment [7]. The mineral crystals form bioactive ceramics hydroxyapatite, which precipitates around the collagen fibers of the osteoid, which provide the strength to the bone [9]. Synthesis and properties of biopolymer composite in order to enhance bone regeneration were studied by Maji, and Dasgupta, the chitosan and gelatin reinforced with hydroxyapatite and crosslinking with glutaraldehyde. No 11, 2019 with genipin and reinforced with nanohydroxyapatie as a biomaterial for bone tissue regeneration
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