Abstract
CeO2-incorporated mesoporous calcium-silicate (CeO2–MCS) materials have been successfully prepared using triblock copolymer (P123) as a structure-directing agent. The effect of CeO2 incorporation on mesoporous structure, in vitro bioactivity, osteoblast cells’ response and drug delivery property of MCS materials were investigated. The results showed that CeO2–MCS materials maintained mesoporous structure with the surface area of 100–200m2/g and pore size peaked at 4–5nm. Furthermore, CeO2–MCS materials had similar apatite-formation ability and sustained drug delivery behavior to MCS materials. Most important, the CeO2 incorporation in MCS materials stimulated the proliferation and alkaline phosphatase (ALP) activity of osteoblast MC3T3-E1 cells. Therefore, CeO2–MCS materials with local drug delivery would be promising for bone regeneration.
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