Abstract
Nanogels of a binary system of carboxymethyl chitosan (CMCh) and poly- (vinyl alcohol) PVA, were successfully synthesized by a novel in situ process. They were also characterized by various analytical tools like Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and X-ray diffraction (XRD). They were studied for their unique swelling properties in water and different pH solutions. They were also investigated for their great ability to capture or isolate bacteria and fungi from aquatic environments.
Highlights
Hydrogels—generally—have the ability to swell in water, retaining a significant fraction of water within their structure without dissolving [1]
A novel method for nanogel synthesis was used to give nanogels based on carboxymethyl chitosan (CMCh) and poly(vinyl alcohol) (PVA) taken in different ratios
Fourier transform infrared spectroscopy (FTIR) spectra of chitosan—Figure 1a—shows two bands at 3445 and 3422 cm−1 corresponding to the –NH2 group, while the spectra of CMCh (Figure 1b) shows a strong peak at 1412 cm−1 which could be assigned to the symmetrical COO− group stretching vibration
Summary
Hydrogels—generally—have the ability to swell in water, retaining a significant fraction of water within their structure without dissolving [1]. Carboxymethyl chitosan has a good solubility in water, and has unique chemical, physical and biological properties such as high viscosity, large hydrodynamic volume, low toxicity, biocompatibility and good ability to form films, fibers and hydrogels [7,8] For this reason, it has been extensively used in many biomedical fields such as a moisture-retention agent, a bactericide, wound dressing agent, artificial bone and skin, blood anticoagulant and as a component in different drug delivery matrices [9,10,11]. Wang et al [16] prepared PVA/CMCS blend films by a mechanical blending method He et al showed that physically crosslinked poly(vinyl alcohol)/chitosan (CS) composite hydrogels were prepared by cyclic freezing/thawing techniques, and the microstructure and swelling behavior of the hydrogels in the simulated gastric (pH 1.0) and intestinal (pH 7.4) media were investigated [17]. Different applications were studied for these nanogels, namely swelling ability at different pH values and their antimicrobial activity
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