Abstract
Small radiolabelled compounds such as peptides are very attractive tools for the diagnosis of several different pathologies (Heppeler in Curr Med Chem 7:971–994, 2000). Among the possible biological targets for radiolabelled compounds, the alpha(v)beta(3) (αvβ3) integrin cell adhesion receptor has been extensively studied. It is expressed on proliferating but not quiescent endothelial cells and has been shown to be involved in tumour progression, angiogenesis and metastasis. The novel radioactive probe 111In-DTPA-RGDechi has been successfully employed for selective αvβ3 single-photon imaging studies. Herein we report the efficient synthetic protocol developed in order to obtain the conjugate diethylentriaminopentacetic acid (DTPA)-RGDechi in good yield and high purity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
