Synthesis and characterization of a modified surface of SBA-15 mesoporous silica for a chloramphenicol drug delivery system

Talib M Albayati,Issam K Salih,Haneen F Alazzawi

doi:10.1016/j.heliyon.2019.e02539

Abstract

In this work, the potential of the modified SBA-15 surface was examined as a sorbent to load the drug from an aqueous solution; this was done using a post-synthesis function procedure. Several means were used to identify the material characterization before and after functionalization, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), BET surface area, Fourier transform infrared (FTIR) spectroscopy and thermal gravimetric analysis (TGA). To obtain the effect of different variables on the efficacy of chloramphenicol drug load, batch adsorption experiments have been performed in a single adsorption system. These variables were the dosage of NH2-SBA-15 (10–120) mg, contact time (0–72 h) and initial concentration (10–120 mg/L). The results of these experiments showed the significant and active effect of the functional amino group in increasing the drug's load capacity. The results of these experiments showed that the functional amino group had a significant and active effect in increasing the drug's capacity. Also, the loading capacity is inversely proportional to the initial concentration, but directly proportional to the NH2-SBA-15 dose and contact time. The best results at 1 hour for the release were 41%. It was found that the load efficiency of chloramphenicol was 51%.

Highlights

Injection and oral administration are the most-used methods of drug delivery for humans
Grafting the internal channels of mesoporous SBA-15 with the amino group did not affect the whole assembly of the ordered mesoporous silica
The X-ray diffraction (XRD) peak intensities of NH2–SBA-15 were basically minimal compared to SBA-15, which is possibly due to the fixing ligands on the outer surface of SBA-15 or the pore-filling effect of SBA-15 channels [32]

Summary

Introduction

Injection and oral administration are the most-used methods of drug delivery for humans. Mesoporous silica is believed to be a good nominee to deliver and release drugs because of favorable features that may help decrease adverse reactions and undesired side effects that many traditional drugs pose. Since their detection in the early 1990s [15], mesoporous silicates as MCM-41, MCM-48, and SBA-15 have attracted the attention of scientists as drug delivery vehicles [16] because of features such as high surface area (typically 1000 m2/g), high porosity (pore volumes 0.5–1.5 cm3/g), well ordered, tunable pores (typically 2–15 nm pore diameter) [17, 18, 19], and ‘‘non cytotoxic’’ properties [20, 21]. Studies appear to show that the loading and releasing properties of a drug depend on the surface chemical nature, specific surface area, size, pore structure, and morphology of mesoporous silica particles [23, 24, 25, 26]

Methods

Results

Conclusion