Abstract
In this research, we conducted a systematic evaluation of the synthesis parameters of a multi-responsive core-shell nanocomposite (Fe3O4 nanoparticles coated by poly(N-isopropylacrylamide) (PNIPAM) in the presence of chitosan (CS) (Fe3O4@PNIPAM-CS). Scanning electron microscopy (SEM) was used to follow the size and morphology of the nanocomposite. The functionalization and the coating of Fe3O4 nanoparticles (Nps) were evaluated by the ζ-potential evolution and Fourier Transform infrared spectroscopy (FTIR). The nanocomposite exhibited a collapsed structure when the temperature was driven above the lower critical solution temperature (LCST), determined by dynamic light scattering (DLS). The LCST was successfully shifted from 33 to 39 °C, which opens the possibility of using it in physiological systems. A magnetometry test was performed to confirm the superparamagnetic behavior at room temperature. The obtained systems allow the possibility to control specific properties, such as particle size and morphology. Finally, we performed vincristine sulfate loading and release tests. Mathematical analysis reveals a two-stage structural-relaxation release model beyond the LCST. In contrast, a temperature of 25 °C promotes the diffusional release model. As a result, a more in-depth comprehension of the release kinetics was achieved. The synthesis and study of a magnetic core-shell nanoplatform offer a smart material as an alternative targeted release therapy due to its thermomagnetic properties.
Highlights
Nanometric scale research has opened a promising perspective on understanding the behavior of matter at this level
Briceño et al, (2017) report a study of magnetite nanoparticle degradation in a biomimetic medium; this study shows that nanoparticles that were not covered with oleic acid (OA) show rapid degradation in the first 24 h, while those that were coated with OA show slow degradation of up to 480 h [25]
Shows a typical collapse induced by hydrophobic interactions in aqueous media at a temperature of 33 ◦ C
Summary
Nanometric scale research has opened a promising perspective on understanding the behavior of matter at this level. It has been observed that, at regular or macro size, the properties of a material with the same chemical composition are different than when presented as nanostructures [1]. Its main outstanding property is the increase in surface contact because hundreds of atoms are located on the surface of the nanostructures, available to react per square centimeter. These nanostructures and their properties are beginning to be used regularly, as they can be applied in a wide range of disciplines. CS can be highlighted, widely known, and applied in biomedicine due to its biocompatibility, biodegradability, and adhesiveness, among other favorable properties. That is why CS can undergo different modifications to increase its physicochemical properties such as solubility, porosity, and architectural forms, among others [11]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
