Abstract
We designed a 68Ga labeled Fe3O4 nano-biocomposite for dual applications as diagnostic imaging agent in positron emission tomography (PET)/magnetic resonance imaging (MRI). The nano-biocomposites (68GaNHFCNP) were fabricated via surface modified iron oxide nanoparticles and NOTA as bi-functional chelating agent with 68Ga isotopes from 68Ge/68Ga generator. The structure and morphological properties of nano-biocomposite was characterized by XRD, TEM and IR analysis. 68GaNHFCNPs exhibits very low cytotoxicity and high cellular uptake upon SK-BR-3 and CT-26 cell lines. The advantages of high biocompatibility, magnetism and cell uptake make this composite promising as a potential probe of PET/MRI for effective detection of cancer.
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