Synthesis and Characterization of 3 - Substituted Coumarin

Shatha Zobaydi,Ban Ismael,Kawther Al-Hammed

doi:10.21123/bsj.2016.13.1.0089

Abstract

The reaction of(2-oxo-2H-chromen-3-Carbonyl chloride)(k1) with hydrazine in boiling ethanol gives the hydrazide(K2).When compound (k2) reacts with various aromatic aldehydes ,the corres ponding Schiff bases(k3–k4) achieve new series of thiazotidines (k5–k6) and azetidinones (k7–k8) obtained from the reactions of appropriate Schiff bases with mercapto acetic acid and chloro acetyl chloride respectively. All the compounds are characterized by FT-IR,1H-NMR and GC-Ms.

Highlights

Coumarin exists in two figures as seen in scheme[1]
Coumarin is firstly synthesized by the chemist Perkin in 1868 in a reaction known as the perkin reaction .Coumarou is a French term for the tonka bean, one of the sources from which Coumarin was dissociated as a natural product in 1820.It has a junket odor, readily acclaimed as the scent of new-mown thatch, and been used since 1882
Sweet woodruff, sweet cannabis and sweet-trefoil in particular are named for their sweet smell, which in turn is due to their high Coumarin contextual.When it happen in high concentrations in fodder plants, Coumarin is a somewhat bitter-palate appetite oppressor,and to be produced by plants as chemical defending to dissuade predation [2]. was isolated (Hermiain) from the Matricaria plant and in disembodies of justicia pectorlis [3,4]

Summary

Introduction

Coumarin exists in two figures as seen in scheme[1]. The Coumarins were found in the enzyme by a gene type that has glucose activities with many trivets including Coumarins[5]. Coumarin has different characteristics in plants may detract the impact of grazing animals. The compound has sweet perfume, it has an astringent savour, which animals birl to avoid it[6], so it should be avoided in alginate food type for animals. Coumarins have shown catalogs of some biological. Activities, were recognized for few medical needs as pharmaceuticals. They are used as an anticarcinogenic agent and in treatment of edema and asthma[7]

Materials and Methods

Results and Discussion

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