Synthesis and Characterization of 2‐(2′‐hydroxy‐5′‐chlorophenyl)‐6‐chloro‐4(3 H)‐Quinazolinone‐Based Fluorogenic Probes for Cellular Imaging of Monoamine Oxidases

Abstract

Monoamine oxidases (MAOs) catalyze the oxidative deamination of neurotransmitters and biogenic amines. A new class of activity-based fluorescent probes based on the alkylation of 2-(2′-hydroxyphenyl)-4(3 H)-quinazolinone (HPQ) with primary, secondary, or tertiary amines is presented for real-time imaging of MAO activity in living cells. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.