Abstract
Objective: The aim of this study is to investigate the growth, structure, spectral, solubility and biological activity of sodium cadmium oxalate dehydrate (NaCdOx) and cadmium oxalate trihydrate (CdOx) crystals prepared by a single diffusion method in the silica gel medium.Methods: The present crystals were grown using single diffusion methods and tested for XRD, UV absorption (190 to 1100 mm) and solubility (distilled water at 20-29 °C) studies. The antimicrobial efficacy of the grown samples at various concentrations (25, 50, 75 and 100 μg/ml) was studied against Streptococcus, (G+Ve), Pseudomonas aeruginosa (G-Ve) and Candida albicans (antifungal). The cytotoxicity evolution was carried out against human cervical cancer cell line (HeLa) using MTT assays.Results: The existing single crystals were successfully grown by silica gel technique. The solubility of sodium cadmium oxalate dehydrate (NaCdOx) was moderately good in deionized warm water. The FTIR spectral studies confirmed the chelating bands of the present samples and UV spectra showed the better the optical conductivity of as-grown crystals. The complexes showed good antimicrobial activity against all tested microbial strains and they exhibited a decrease in cytotoxicity activity.Conclusion: The gel method was suitable to grow metal complexes of legend crystals. The modification of structural properties of cadmium oxalate trihydrate (CdOx) by sodium doping was much improved the solubility, anticancer, antimicrobial activity and polarization by the high optical conductivity of sodium cadmium oxalate dehydrate (NaCdOx) compound. Hence sodium cadmium oxalate dehydrate (NaCdOx) might be a candidate for biomedical applications.
Highlights
IntroductionBut sparsely distributed element found in the earth's crust at concentrations ranging from 0.1 to 1 ppm
Cadmium is a widely, but sparsely distributed element found in the earth's crust at concentrations ranging from 0.1 to 1 ppm
The single crystals of cadmium oxalate trihydrate (CdOx) and sodium cadmium oxalate dihydrate (NaCdOx) were grown by silica gel medium and the results of the structural analysis were indicated that by adding sodium, the triclinic structure of cadmium oxalate trihydrate (CdOx) transformed to the monoclinic structure was confirmed by single crystal x-ray diffraction (SXRD) diffraction studies
Summary
But sparsely distributed element found in the earth's crust at concentrations ranging from 0.1 to 1 ppm. A kind of organic acid, which has often played a major role in alleviating metal toxicity via a variation of the mobility and bioavailability of heavy metals [1, 2] It is a natural chemotherapy void of troubling side effects and is a usual element in human blood and must be accessible for the immune system to fight against the diseases of cancer, viral, bacterial and vascular conditions. It has a mean value of 288 mg of anhydrous oxalic acid/100 ml of blood. To the best of our knowledge, we report the structural, optical and biological properties of cadmium mixed chelating compounds
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