Abstract
Photo-cleavable polymers containing 5-hydroxy-2-nitrobenzyl alcohol (ONB) junction point between the target molecule of folic acid (FA) and the hydrophobic poly(4-substituted-ɛ-caprolactone) (PXCLn) chain were synthesized. FA –terminated ONB-PXCLn polymers formed micelles with critical micelle concentration (CMC) 1.2 – 64.3 mg L−1. Fluorescence emission spectroscopy indicated the release of Nile red encapsulated FA-ONB-PXCLn micelles in response to irradiation. Light-triggered bursts released were observed for drug-loaded FA-ONB-PXCLn micelles. The nanoparticles exhibited nonsignificant toxicity at concentrations up to 300 µg mL−1. Flow cytometry revealed that the uptake of folate-targeted doxorubicin (DOX) -encapsulated micelles by HeLa cells was faster than that of free DOX.
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