Abstract
CM-1,3-β-Glucan was synthesis by introducing carboxy methyl group with molar ratio of monochloroacetic acid, and cytotoxicity, antioxidant, whitening effect, anti-inflammation, and anti-wrinkle characteristics were examined It was confirmed that carboxymethyl was quantitatively introduced to β-glucan. As a result of conducting test on cell stability of human keratinocyte cell lines (HaCaT), it did not present cytoxicity at both 0.1% and 0.5% concentration compared to control group and it was revealed to have no cytotoxicity at all. Presented high cell proliferation rate compared to control group at 0.1% concentration. Although anti-inflammation effect was confirmed with the reduction of COX-2 expression in CMB-1, CMB-5, CMB-6, CMBA-1, and CMBA-3 at 0.1% concentration as a result of conducting COX-2 expression influence test against animal cells, an anti-inflammatory test, it was revealed to have no effect in other substances. As a result of conducting MMP-1 expression influence test, an anti-wrinkle test, great anti-wrinkle effect was confirmed as MMI expression reduced in CMR-1, CMB-2, CMB-3, CMB-4, CMB-6, CMBA-1, and CMBA3 at 0.1% concentration and CMB-1, CMB-2, CMB-3, CMB-4, and CMBA-1 at 0.5% concentration.
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