Synthesis and characterisation of poly(lactide-co-glycolide) nanospheres using vitamin E emulsifier prepared through one-step oil-in-water emulsion and solvent evaporation techniques.

Abstract

Nanoparticulate drug delivery systems are of considerable therapeutic interest for delivery of drugs across from the blood-brain barrier. In this study, the ability of sodium chloride (NaCl) and different percentages of a water-soluble form of natural vitamin E, on the formation of poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs), as a potential carrier for drug delivery, was investigated. According to the obtained results, by increasing the percentage of natural vitamin E, the average particle size decreased and the range of diameters came closer. After using 0.26 w/v % vitamin E, the average size of the PLGA particles became <100 nm. Moreover, the particles containing NaCl led to the formation of even smaller particles. In addition, no obvious cytotoxicity was observed at various natural vitamin E amounts in one and three days, and the modified PLGA NPs could be considered biocompatible since they showed a little decrease in cellular viability.