Abstract
In this work, the fluorescent hydroxyapatite nanoparticles (HA NPs) were synthesised by doping cerium (Ce) ions into the crystal structure of HA at different concentrations. The fluorescent property of the Ce-doped HA NPs was determined by the content of Ce doping. The results show that HA NPs with the Ce-doping content of 5% displayed the highest fluorescent emission peak near 380 nm at the excitation wavelength of 300 nm. The CCK-8 assay showed that no significant cytotoxicity was observed when the L929 cells were incubated with the fluorescent HA NPs with the Ce-doping content of 5% for 12 h at the dose lower than 0.1 mg/ml. Therefore, the fluorescent HA NPs could be used as a fluorescent probing for cellular imaging and antioxidant agent against oxidative stress-induced cell damages.
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