Abstract
Quaternary ammonium salts have been obtained via the reaction of drotaverine base and its tetrahydroisoquinoline derivative with alkyl iodides. Boiling of drotaverine with HBr leads to the cleavage of ethoxy groups with the formation of hydroxy groups. It is established that all the synthesized compounds increase blood coagulation. For the most active compounds, the effect reaches 26%.
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