Synthesis and biological response of chlorophyll derivatives for use in photodynamic therapy studies

Abstract

s / Photodiagnosis and Photodynamic Therapy 12 (2015) 325–375 359 as a potential photosensitizer. TLD1433 binding to transferrin results in increased absorption in the green spectrum and de novo absorption in the red and near infrared spectral range. Bleaching resistance and reactive oxygen species production are both increased after TLD1433 binding to transferrin. In vitro PDT AY27 cell culture experiments show that addition of transferrin to TLD1433 results in reduced dark toxicity and increased PDT mediated cell kill, showing that transferrin can increase efficacy of TLD1433. Subsequent testing of TLD1433 PDT efficacy in an in vivo mouse model revealed that TLD1433 bound to transferrin was able to increase the tumor free survival time of mice compared to TLD1433 alone at identical radiant exposures. Our combined findings place transferrin as a novel component in TLD1433 mediated PDT therapy, increasing the efficacy of TLD1433. http://dx.doi.org/10.1016/j.pdpdt.2015.07.133 New formulations nanostructured containing curcumin for optimization in photodynamic therapy Isabella Suzuki, Natalia Inada, Valeria Marangoni, Ana Paula da Silva, Thaila Correa, Valtencir Zucolotto, Cristina Kurachi, Vanderlei Bagnato Sao Carlos Institute of Physics, University of Sao