Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of arg-gly-asp (RGD)

Naoyuki Nishikawa,Hiroyuki Komazawa,Atsushi Orikasa,Mitsuo Yoshikane,Jiro Yamaguchi,Masayoshi Kojima,Mitsunori Ono,Isamu Itoh,Ichiro Azuma,Hideki Fujii,Jun Murata,Ikuo Saiki

doi:10.1016/s0960-894x(96)00494-5

Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of arg-gly-asp (RGD)

Naoyuki Nishikawa, Hiroyuki Komazawa + Show 10 more

https://doi.org/10.1016/s0960-894x(96)00494-5

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Journal: Bioorganic & Medicinal Chemistry Letters	Publication Date: Nov 1, 1996
Citations: 10

Affiliation: Fujifilm (Japan), Hokkaido University, Tohoku Medical and Pharmaceutical University

#Retro-inverso Peptides #Induced Platelet Aggregation + Show 8 more

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Abstract

Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects of experimental lung metastasis of murine melanoma and adenosine 5′-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient theraputic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation.

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