Synthesis and Biological Evaluation of the Selected Naphthalene Substituted Azetidinone Derivatives Targeting Parkinson’s Disease

Abstract

Abstract: Aim/Background: Parkinson’s Disease (PD), the loss of dopaminergic neurons in the substantial nigra part of the brain leading to neurodegeneration. Materials and Methods: The objective of this study was to observe the neuroprotective effect of the synthesized derivatives in 6-hydroxydopamine (6-OHDA) induced rat model. Here, designed naphthalene substituted azetidinone compounds defended the lesions caused by 6-OHDA in rat model for PD. Male wistar rats (250g) were subjected into sham operated, controlled 6-OHDA, 6-OHDA treated L-dopa (Levodopa) and lesioned 6-OHDA with azetidinone derivatives (30mg/kg) where oxidative stress and behavioral characteristic were observed. Results: Induced synthesized derivatives partly have shown the reversed behavioral and neuronal changes compared to 6-OHDA lesioned rats. The free radical scavenging activity for the compound IVc, IVe and IVf were found to be 88, 70, 78 respectively as compared to that of 6-OHDA with L-dopa with 90%. Conclusion: The efficacy of the azetidinone derivatives was found to be promising in providing relief to oxidative stress and the derivatives could be used in the therapeutic approaches in preventing neurodegeneration. Keywords: Schiff’s bases, Azetidinone, Anti-Parkinson’s activity, Neurodegeneration, 6-OHDA.