Abstract

 In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The N-Mannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The compounds were tested for their possible antibacterial, analgesic and anti-inflammatory activities by the standard methods. Among the tested compounds, the compound containing the chloro group showed significant biological activity. These pilot studies demonstrate the usefulness of isatin-based Mannich bases. 
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