Abstract
The synthesis of all stereoisomeric 25,26-epoxy-1α,24-dihydroxyvitamin D 3 analogues is described and relies on the Sharpless kinetic resolution of secondary alcohols. It further includes the Julia procedure for side chain construction and the Lythgoe A-ring coupling procedure. Biological evaluation includes the study of calcemic effect, receptor binding and cell differentiation. The synthesis and biological activities of vitamin D 3 analogues containing 25,26-epoxy function (X = OH or H) are presented.
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