Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones

Anna Bielenica

doi:10.3797/scipharm.1012-17

Abstract

A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.

Highlights

Literature survey shows that phenylpiperazinyl group is a nuclei of antiviral, antibacterial and antifungal [1,2,3] agents
Derivatives of diarylpiperidin-4-one were found as the new class of antimicrobial agents with activity against pathogenic bacterial species and fungal
There is an increasing concern on substituted 4-arylpiperazines, 4-azatricyclodec-8-ene-3,5-dione derivatives, as some of them have been reported as antiviral agents, e.g. against Yellow Fever Virus (YFV) and Border Disease Virus (CVB-2), as well as antibacterial and antifungal compounds [1, 15]

Summary

Introduction

Literature survey shows that phenylpiperazinyl group is a nuclei of antiviral, antibacterial and antifungal [1,2,3] agents. There is an increasing concern on substituted 4-arylpiperazines, 4-azatricyclodec-8-ene-3,5-dione derivatives, as some of them have been reported as antiviral agents, e.g. against Yellow Fever Virus (YFV) and Border Disease Virus (CVB-2), as well as antibacterial and antifungal compounds [1, 15]. N-substituted derivatives of 3-phenylpiperidine-2,6-dione, were evaluated in vitro against viruses, bacteria and fungi.

Results

Conclusion